Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder in which autoantibodies and/or autoreactive T cells destroy platelets and megakaryocytes in the spleen and bone marrow, respectively. Thrombopoietin receptor agonists (TPO-RA e.g. Romiplostim and Eltrombopag) have made a substantial co...

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Principais autores:	Rick Kapur, Rukhsana Aslam, Edwin R. Speck, Johan M. Rebetz, John W. Semple
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2020-04-01
coleção:	Platelets
Assuntos:	immune thrombocytopenia (itp) immunomodulation platelet antibodies platelet counts thrombopoietin receptor agonist (tpo-ra)
Acesso em linha:	http://dx.doi.org/10.1080/09537104.2019.1624709
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