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Human Skin Permeation Enhancement Using PLGA Nanoparticles Is Mediated by Local pH Changes

The steady improvement and optimization of transdermal permeation is a constant and challenging pharmaceutical task. In this study the influence of poly(lactide-co-glycolide) (PLGA) nanoparticles on the dermal permeation of the anti-inflammatory drug flufenamic acid (FFA) was investigated. For this...

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Principais autores: Javiana Luengo, Marc Schneider, Anna M. Schneider, Claus-Michael Lehr, Ulrich F. Schaefer
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2021-10-01
coleção:Pharmaceutics
Assuntos:
PLGA
polymer nanoparticles
pH effects
human skin
permeation
penetration
Acesso em linha:https://www.mdpi.com/1999-4923/13/10/1608
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