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Aging affects GABAergic function and calcium homeostasis in the mammalian central clock

IntroductionAging impairs the function of the central circadian clock in mammals, the suprachiasmatic nucleus (SCN), leading to a reduction in the output signal. The weaker timing signal from the SCN results in a decline in rhythm strength in many physiological functions, including sleep–wake patter...

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Hauptverfasser: Anneke H. O. Olde Engberink, Pablo de Torres Gutiérrez, Anna Chiosso, Ankita Das, Johanna H. Meijer, Stephan Michel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2023-05-01
Schriftenreihe:Frontiers in Neuroscience
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Online-Zugang:https://www.frontiersin.org/articles/10.3389/fnins.2023.1178457/full
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