Effects of metformin on transcriptomic and metabolomic profiles in breast cancer survivors enrolled in the randomized placebo-controlled MetBreCS trial

Abstract Metformin reduces the incidence of breast cancer in patients with obesity and type 2 diabetes. However, our knowledge of the effects of metformin on breast cancer recurrence is limited. Within the randomized double-blind placebo-controlled phase II trial MetBreCS, we examined changes in bre...

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Autors principals:	Pouda Panahandeh Strømland, Bjørn-Erik Bertelsen, Kristin Viste, Anastasia Chrysovalantou Chatziioannou, Federica Bellerba, Nivonirina Robinot, Amarine Trolat, Marianne Hauglid Flågeng, Augustin Scalbert, Pekka Keski-Rahkonen, Dorothy D. Sears, Bernardo Bonanni, Sara Gandini, Harriet Johansson, Gunnar Mellgren
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-05-01
Col·lecció:	Scientific Reports
Matèries:	Metformin Breast cancer recurrence Sex steroid hormones 17β-estradiol Estrone Metabolomics
Accés en línia:	https://doi.org/10.1038/s41598-025-01705-9
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