The guide sRNA sequence determines the activity level of box C/D RNPs

2’-O-rRNA methylation, which is essential in eukaryotes and archaea, is catalysed by the Box C/D RNP complex in an RNA-guided manner. Despite the conservation of the methylation sites, the abundance of site-specific modifications shows variability across species and tissues, suggesting that rRNA met...

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Hlavní autoři:	Andrea Graziadei, Frank Gabel, John Kirkpatrick, Teresa Carlomagno
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2020-03-01
Edice:	eLife
Témata:	rRNA methylation integrative structural biology Box C/D RNP conformational equilibrium NMR SAS
On-line přístup:	https://elifesciences.org/articles/50027
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