Conformational Changes Induced by S34Y and R98C Variants in the Death Domain of Myd88

Myeloid differentiating factor 88 (Myd88) is a universal adaptor protein that plays a critical role in innate immunity by mediating TLR downstream signaling. Myd88 death domain (DD) forms an oligomeric complex by association with other DD-containing proteins such as IRAK4. Despite its universal role...

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Autors principals:	Vijayakumar Gosu, KyeongHye Won, Jae-Don Oh, Donghyun Shin
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2020-03-01
Col·lecció:	Frontiers in Molecular Biosciences
Matèries:	Myd88 polymorphism molecular dynamics simulation principal components betweenness centrality
Accés en línia:	https://www.frontiersin.org/article/10.3389/fmolb.2020.00027/full
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