Inhibition of SREBP Improves Cardiac Lipidopathy, Improves Endoplasmic Reticulum Stress, and Modulates Chronic Chagas Cardiomyopathy

Background Trypanosoma cruzi is an intracellular parasite that causes debilitating chronic Chagas cardiomyopathy (CCM), for which there is no effective drug or vaccine. Previously, we demonstrated increased cardiac lipid accumulation and endoplasmic reticulum stress in mice with CCM. Increased endop...

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Autors principals:	Janeesh Plakkal Ayyappan, Kezia Lizardo, Sean Wang, Edward Yurkow, Jyothi F. Nagajyothi
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2020-02-01
Col·lecció:	Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Matèries:	betulin cardiomyopathy Chagas disease endoplasmic reticulum stress mitochondrial stress SREBP activation
Accés en línia:	https://www.ahajournals.org/doi/10.1161/JAHA.119.014255
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