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Study of Flavonoid in Apium graveolens L. as a Kirsten Rat Sarcoma Protein Inhibitor in Colorectal Cancer Based on In Silico Study

Colorectal cancer (CRC) is considered the second deadliest cancer, mainly caused by the mutation of Kirsten Rat Sarcoma (KRAS) type G12D; it’s still undruggable. Flavonoids are secondary metabolites in celery, consisting of apigenin, luteolin, quercetin, and kaempferol. This study aims to analyse th...

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Hlavní autoři: Abdullah Abdullah, Nenis Try Melani Putri, Nuraini Rosyadah, Putri Ramadhani, Siti Aqila Kharisma Putri, Muhammad Hermawan Widyananda, Nia Kurniawan, Fatchiyah Fatchiyah
Médium: Artigo
Jazyk:Inglês
Vydáno: Biology Department, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya 2023-10-01
Edice:Biotropika: Journal of Tropical Biology
Témata:
binding affinity
colorectal cancer
flavonoid
inhibition
kirsten rat sarcoma
On-line přístup:https://biotropika.ub.ac.id/index.php/biotropika/article/view/1385
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