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Cellular and Molecular Mechanisms of SARS-CoV-2 Spike Protein-Induced Endothelial Dysfunction

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is initiated by the viral spike proteins, which are key structural components that mediate host cell binding and entry and alter downstream signaling through multiple interactions with endothelial surface receptors. Endothelial d...

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Main Authors: Kelsey C. Muir, Dwight D. Harris, Meghamsh Kanuparthy, Jiayu Hu, Ju-Woo Nho, Christopher Stone, Debolina Banerjee, Frank W. Sellke, Jun Feng
Format: Artigo
Language:Inglês
Published: MDPI AG 2026-01-01
Series:Cells
Subjects:
spike protein
SARS-CoV-2
endothelial dysfunction
COVID-19
endothelial permeability
Online Access:https://www.mdpi.com/2073-4409/15/3/234
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