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Hypoxic 3D in vitro culture models reveal distinct resistance processes to TKIs in renal cancer cells

Abstract Background The aim of this study is to determine the effect of hypoxia on axitinib and sorafenib-treated renal cell carcinoma (RCC) cells. Hypoxia is a crucial factor influencing transcription process via protein modulation, which was shown i.e. in pancreatic cancer. Until now, hypoxia has...

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Principais autores: Zofia F. Bielecka, Agata Malinowska, Klaudia K. Brodaczewska, Aleksandra Klemba, Claudine Kieda, Paweł Krasowski, Elżbieta Grzesiuk, Jan Piwowarski, Anna M. Czarnecka, Cezary Szczylik
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2017-12-01
coleção:Cell & Bioscience
Assuntos:
Hypoxia
Tyrosine kinase inhibitors
Drug resistance
3D cell culture
Renal cell carcinoma
Papillary
Acesso em linha:http://link.springer.com/article/10.1186/s13578-017-0197-8
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