Antitumor Effect of Anti‐c‐Myc Aptamer‐Based PROTAC for Degradation of the c‐Myc Protein

Abstract Targeting “undruggable” targets with intrinsically disordered structures is of great significance for the treatment of disease. The transcription factor c‐Myc controls global gene expression and is an attractive therapeutic target for multiple types of cancers. However, due to the lack of d...

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Bibliografische Detailangaben

Hauptverfasser:	Yuchun Wang, Gang Yang, Xinyu Zhang, Ruoling Bai, Deyu Yuan, Denghui Gao, Qianyu He, Yi Yuan, Xinghe Zhang, Junchuang Kou, Lihua Zheng, Yanxin Huang, Zhuo Tang, Yongli Bao, Xu Song, Yongyun Zhao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2024-07-01
Schriftenreihe:	Advanced Science
Schlagworte:	aptamer‐based PROTAC c‐Myc aptamer c‐Myc degradation microwell‐SELEX undruggable
Online-Zugang:	https://doi.org/10.1002/advs.202309639
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