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IFN-γ-mediated inhibition of JAK/STAT signaling via nano-scutellarin treatment is an efficient strategy for ameliorating liver fibrosis

Abstract Background Metabolic dysfunction-associated steatohepatitis (MASH) is a large group of metabolic diseases that are hazardous to human health. Endothelial-to-mesenchymal transition (EndMT) mediated myofibroblast activation is an important factor that aggravates the development of liver fibro...

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Principais autores: Ting Wang, Bangguo Liu, Juan Huang, Qixin Zhao, Hongping Shen, Tao Bi, Zengjin Liu, Yong Dai, Qin Sun
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-02-01
Serier:Journal of Translational Medicine
Fag:
MASH
EndMT
Interferon-γ
HUVECs
JAK
STAT1
Online adgang:https://doi.org/10.1186/s12967-025-06155-5
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