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Reticulophagy receptor FAM134C restrains BMP receptor signaling

Abstract FAM134/RETREG family members are ER-phagy receptors that maintain cellular homeostasis by regulating endoplasmic reticulum turnover. However, possible non-ER-phagy functions of FAM134 proteins remain elusive. Here, we show that RETREG3/FAM134C functions as a selective autophagy receptor for...

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Hoofdauteurs: Shuchen Gu, Hanchenxi Zhang, Jin Cao, Zhou He, Jianfeng Wu, Xia Liu, Mingjie Zheng, Ting Liu, Bin Zhao, Pinglong Xu, Qiming Sun, Jianping Jin, Xia Lin, Yi Yu, Jiahuai Han, Xin-Hua Feng
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer Nature 2025-10-01
Reeks:The EMBO Journal
Onderwerpen:
RETREG
TGF-β
Smad
Autophagy
Degradation
Online toegang:https://doi.org/10.1038/s44318-025-00581-3
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