Targeting CXCR4 potentiates anti-PD-1 efficacy modifying the tumor microenvironment and inhibiting neoplastic PD-1

Abstract Background Inefficient T-cell access to the tumor microenvironment (TME) is among the causes of tumor immune-resistance. Previous evidence demonstrated that targeting CXCR4 improves anti-PD-1/PD-L1 efficacy reshaping TME. To evaluate the role of newly developed CXCR4 antagonists (PCT/IB2011...

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Autori principali:	Crescenzo D’Alterio, Maria Buoncervello, Caterina Ieranò, Maria Napolitano, Luigi Portella, Giuseppina Rea, Antonio Barbieri, Antonio Luciano, Giosuè Scognamiglio, Fabiana Tatangelo, Anna Maria Anniciello, Mario Monaco, Ernesta Cavalcanti, Piera Maiolino, Giulia Romagnoli, Claudio Arra, Gerardo Botti, Lucia Gabriele, Stefania Scala
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2019-10-01
Serie:	Journal of Experimental & Clinical Cancer Research
Soggetti:	Tumor microenvironment Immune privilege Tumor infiltrating lymphocytes Treg MDSC; CXCR4-CXCL12 pathway Tumor intrinsic PD-1 pathway
Accesso online:	http://link.springer.com/article/10.1186/s13046-019-1420-8
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