The CUL5 ubiquitin ligase complex mediates resistance to CDK9 and MCL1 inhibitors in lung cancer cells

Overexpression of anti-apoptotic proteins MCL1 and Bcl-xL are frequently observed in many cancers. Inhibitors targeting MCL1 are in clinical development, however numerous cancer models are intrinsically resistant to this approach. To discover mechanisms underlying resistance to MCL1 inhibition, we p...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Shaheen Kabir, Justin Cidado, Courtney Andersen, Cortni Dick, Pei-Chun Lin, Therese Mitros, Hong Ma, Seung Hyun Baik, Matthew A Belmonte, Lisa Drew, Jacob E Corn
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	eLife Sciences Publications Ltd 2019-07-01
Schriftenreihe:	eLife
Schlagworte:	MCL1 inhibitor genome-wide CRISPRi screens CUL5-RNF7-UBE2F ubiquitin ligase complex CDK9 inhibitor noxa bim
Online-Zugang:	https://elifesciences.org/articles/44288
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