Retinal damage promotes mitochondrial transfer in the visual system of a mouse model of Leber hereditary optic neuropathy

Lenadogene nolparvovec is a gene therapy which has been developed to treat Leber hereditary optic neuropathy (LHON) caused by a point mutation in the mitochondrial NADH dehydrogenase 4 (ND4) gene. Clinical trials have demonstrated a significant improvement of visual acuity up to 5 years after treatm...

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Autores principales:	Pascal Ezan, Eléonore Hardy, Alexis Bemelmans, Magali Taiel, Elena Dossi, Nathalie Rouach
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2024-10-01
Colección:	Neurobiology of Disease
Materias:	Mitochondrial transfer Leber hereditary optic neuropathy Retina Optic nerve Gene therapy Viral vector
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S096999612400281X
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