CHRFAM7A diversifies human immune adaption through Ca2+ signalling and actin cytoskeleton reorganizationResearch in context

Summary: Background: Human restricted genes contribute to human specific traits in the immune system. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of the α7 nicotinic acetylcholine receptor (α7 nAChR), the highest Ca2+ conductor of the ACh receptors implicated in innate immunity....

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Detalhes bibliográficos

Principais autores:	Kinga Szigeti, Ivanna Ihnatovych, Emily Notari, Ryu P. Dorn, Ivan Maly, Muye He, Barbara Birkaya, Shreyas Prasad, Robin Schwartz Byrne, Dinesh C. Indurthi, Erik Nimmer, Yuna Heo, Kolos Retfalvi, Lee Chaves, Norbert Sule, Wilma A. Hofmann, Anthony Auerbach, Gregory Wilding, Yongho Bae, Jessica Reynolds
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2024-05-01
coleção:	EBioMedicine
Assuntos:	Human immune diversity CHRFAM7A Ca2+ signalling Actin cytoskeleton Adaptation to the mechanical properties Translational significance
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352396424001282
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