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Lsr2, a pleiotropic regulator at the core of the infectious strategy of Mycobacterium abscessus

ABSTRACTMycobacterium abscessus is a non-tuberculous mycobacterium, causing lung infections in cystic fibrosis patients. During pulmonary infection, M. abscessus switches from smooth (Mabs-S) to rough (Mabs-R) morphotypes, the latter being hyper-virulent. Previously, we isolated the lsr2 gene as dif...

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Principais autores: Elias Gerges, María del Pilar Rodríguez-Ordoñez, Nicolas Durand, Jean-Louis Herrmann, Frédéric Crémazy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2024-03-01
coleção:Microbiology Spectrum
Assuntos:
Mycobacterium abscessus
S/R morphotypes
Lsr2
nucleoid-associated protein
transcription factor
antibiotic resistance
Acesso em linha:https://journals.asm.org/doi/10.1128/spectrum.03528-23
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