Reduced-Beclin1-Expressing Mice Infected with Zika-R103451 and Viral-Associated Pathology during Pregnancy

Here, we used a mouse model with defective autophagy to further decipher the role of Beclin1 in the infection and disease of Zika virus (ZIKV)-R103451. Hemizygous (<i>Becn1</i>^+/−) and wild-type (<i>Becn1</i>^+/+) pregnant mice were transiently immunocompromised using the anti-i...

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Hlavní autoři:	Mohan Kumar Muthu Karuppan, Chet Raj Ojha, Myosotys Rodriguez, Jessica Lapierre, M. Javad Aman, Fatah Kashanchi, Michal Toborek, Madhavan Nair, Nazira El-Hage
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-06-01
Edice:	Viruses
Témata:	Zika virus autophagy-defective mouse-model Beclin1 microcephaly inflammatory molecules growth factor
On-line přístup:	https://www.mdpi.com/1999-4915/12/6/608
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