Acetyl-CoA synthetase mutations affect the susceptibility of Plasmodium falciparum to antimalarial drugs

ABSTRACT Plasmodium falciparum acetyl-CoA synthetase (PfAcAS) is an important source of acetyl-CoA. We detected mutations S868G and V950I in PfAcAS by whole-genome sequencing analysis in certain recrudescent parasites after treatment with artesunate and dihydroartemisinin-piperaquine. Using CRISPR/C...

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Bibliografische gegevens

Hoofdauteurs:	Wei Zhao, Zheng Xiang, Weilin Zeng, Yucheng Qin, Maohua Pan, Yanrui Wu, Mengxi Duan, Ye Mou, Tao Liang, Yanmei Zhang, Cheng Liu, Xiuya Tang, Yaming Huang, Gongchao Yang, Liwang Cui, Zhaoqing Yang
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	American Society for Microbiology 2025-10-01
Reeks:	Microbiology Spectrum
Onderwerpen:	Acetyl-CoA synthetase Plasmodium falciparum artemisinin drug resistance
Online toegang:	https://journals.asm.org/doi/10.1128/spectrum.01026-25
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