Lamin A/C facilitates DNA damage response by modulating ATM signaling and homologous recombination pathways

Lamin A/C, a core component of the nuclear lamina, forms a mesh-like structure beneath the inner nuclear membrane. While its structural role is well-studied, its involvement in DNA metabolism remains unclear. We conducted sequential protein fractionation to determine the subcellular localization of...

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Hlavní autoři:	Seong-jung Kim, Su Hyung Park, Kyungjae Myung, Kyoo-young Lee
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2024-12-01
Edice:	Animal Cells and Systems
Témata:	DNA damage response (DDR) Lamin A/C ATM MRN complex
On-line přístup:	https://www.tandfonline.com/doi/10.1080/19768354.2024.2393820
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