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Tracing the cellular basis of islet specification in mouse pancreas

The cellular basis of islet morphogenesis and fate allocation remain unclear. Here, the authors use a R26-CreER-R26R-Confetti mouse line to follow quantitatively the clonal dynamics of islet formation showing how, during the secondary transition, islet progenitors amplify through rounds of stochasti...

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Bibliografiske detaljer
Principais autores: Magdalena K. Sznurkowska, Edouard Hannezo, Roberta Azzarelli, Lemonia Chatzeli, Tatsuro Ikeda, Shosei Yoshida, Anna Philpott, Benjamin D. Simons
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2020-10-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-020-18837-3
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