Repurposing ribosome-targeting antibiotics to overcome resistance to venetoclax in acute myeloid leukemia

Venetoclax, a selective B-cell lymphoma 2 inhibitor, has shown promise in the treatment of acute myeloid leukemia. However, the development of drug resistance limits its clinical efficacy. In our study, we discovered that ribosome-targeting antibiotics can be repurposed to overcome venetoclax resist...

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Detalhes bibliográficos

Principais autores:	David Sharon, Steven M. Chan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2020-03-01
coleção:	Molecular & Cellular Oncology
Assuntos:	acute myeloid leukemia bcl-2 inhibitor drug resistance integrated stress response antibiotics mitochondrial translation
Acesso em linha:	http://dx.doi.org/10.1080/23723556.2020.1712182
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