Shear stress and pathophysiological PI3K involvement in vascular malformations
Molecular characterization of vascular anomalies has revealed that affected endothelial cells (ECs) harbor gain-of-function (GOF) mutations in the gene encoding the catalytic α subunit of PI3Kα (PIK3CA). These PIK3CA mutations are known to cause solid cancers when occurring in other tissues. PIK3CA-...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society for Clinical Investigation
2024-05-01
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| Edice: | The Journal of Clinical Investigation |
| On-line přístup: | https://doi.org/10.1172/JCI172843 |
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