Reshaping the Battlefield: Reprogramming the Melanoma Tumour Microenvironment (TME) by Anti-CTLA-4, Anti-PD-1, and Anti-PD-L1 Monotherapy and Combination Therapy: A Systematic Review and Meta-Analysis of Preclinical and Clinical Evidence

Immune checkpoint inhibitors (ICIs), comprising anti-cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), anti-programmed cell death protein 1 (PD-1), and anti-programmed death-ligand 1 (PD-L1), have transformed melanoma therapy, yet the tumour microenvironment (TME), the pivotal biological interfa...

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Autori principali:	Vasileios Alexandros Karakousis, Stylianos Mantalovas, Vasiliki Christina Karakousi, Ioannis S. Vizirianakis, Theodora Papamitsou, Leonidas Pavlidis, Christophoros S. Kosmidis
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-06-01
Serie:	Cells
Soggetti:	melanoma tumour microenvironment immune checkpoint inhibitors CTLA-4 PD-1 PD-L1
Accesso online:	https://www.mdpi.com/2073-4409/15/13/1182
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