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Prevention of HIV-1 TAT Protein-Induced Peripheral Neuropathy and Mitochondrial Disruption by the Antimuscarinic Pirenzepine

HIV-associated distal sensory polyneuropathy (HIV-DSP) affects about one third of people with HIV and is characterized by distal degeneration of axons. The pathogenesis of HIV-DSP is not known and there is currently no FDA-approved treatment. HIV trans-activator of transcription (TAT) is associated...

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Principais autores: May Madi Han, Katie E. Frizzi, Ronald J. Ellis, Nigel A. Calcutt, Jerel Adam Fields
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-06-01
coleção:Frontiers in Neurology
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Acesso em linha:https://www.frontiersin.org/articles/10.3389/fneur.2021.663373/full
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