Mutant TP53 G245C and R273H promote cellular malignancy in esophageal squamous cell carcinoma

Abstract Background TP53 gene mutations occur in more than 50% of human cancers and the vast majority of these mutations in human cancers are missense mutations, which broadly occur in DNA binding domain (DBD) (Amino acids 102–292) and mainly reside in six “hotspot” residues. TP53 G245C and R273H po...

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主要な著者:	Nan Kang, Yu Wang, Shichao Guo, Yunwei Ou, Guangchao Wang, Jie Chen, Dan Li, Qimin Zhan
フォーマット:	Artigo
言語:	Inglês
出版事項:	BMC 2018-08-01
シリーズ:	BMC Cell Biology
主題:	Esophageal squamous cell carcinoma TP53 mutation Cell malignancy Migration Invasion Apoptosis
オンライン･アクセス:	http://link.springer.com/article/10.1186/s12860-018-0167-y
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