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A Conditionally Activated Cytosol-Penetrating Antibody for TME-Dependent Intracellular Cargo Delivery

Currently, therapeutic and diagnostic applications of antibodies are primarily limited to cell surface-exposed and extracellular proteins. However, research has been conducted on cell-penetrating peptides (CPP), as well as cytosol-penetrating antibodies, to overcome these limitations. In this contex...

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Principais autores: Carolin Sophie Dombrowsky, Dominic Happel, Jan Habermann, Sarah Hofmann, Sasi Otmi, Benny Cohen, Harald Kolmar
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-05-01
Serier:Antibodies
Fag:
cytosol-penetrating antibody
cytosolic delivery
endosomal escape
masked cytosol-penetrating antibody
MMP-9
TME
Online adgang:https://www.mdpi.com/2073-4468/13/2/37
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