Often neglected steps in transforming drug solubility from single measurement in pure water to physiologically-appropriate solubility-pH
Background and purpose: The solubility of weakly-ionizable drugs in pure water, Sw, is commonly measured. The pH-dependent properties of the saturated solutions can be surprisingly complex in subtle ways. This commentary examines the characteristics of such measurements through case studies of 32...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
International Association of Physical Chemists (IAPC)
2025-02-01
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| coleção: | ADMET and DMPK |
| Assuntos: | |
| Acesso em linha: | https://pub.iapchem.org/ojs/index.php/admet/article/view/2626 |
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