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The Adhesion GPCR ADGRL2/LPHN2 Can Protect Against Cellular and Organismal Dysfunction

The most common trigger of sepsis and septic shock is bacterial lipopolysaccharide (LPS). Endothelial cells are among the first to encounter LPS directly. Generally, their function is closely linked to active endothelial NO Synthase (eNOS), which is significantly reduced under septic conditions. LPS...

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Hlavní autoři: Philipp Jakobs, Anne Rafflenbeul, Willem Berend Post, Niloofar Ale-Agha, Victoria Elisabeth Groß, Stephanie Pick, Sascha Dolata, Fiona F. Cox, Florian von Ameln, Olaf Eckermann, Joachim Altschmied, Simone Prömel, Judith Haendeler
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2024-11-01
Edice:Cells
Témata:
ADGRL2/LPHN2
<i>Caenorhabditis elegans</i>
endothelial cells
eNOS
lipopolysaccharide
NRF2
On-line přístup:https://www.mdpi.com/2073-4409/13/22/1826
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