Transmembrane thiol isomerase TMX1 counterbalances the effect of ERp46 to inhibit platelet activation and integrin αIIbβ3 function

Background: Previous studies have shown that thiol isomerases such as ERp46 positively regulate platelet function by reducing integrin αIIbβ3 disulfides, and the transmembrane thiol isomerase TMX1 negatively regulates integrin αIIbβ3 activation. However, whether and how the positive and negative thi...

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Bibliografische Detailangaben

Hauptverfasser:	Zhenzhen Zhao, Yixin Cheng, Yaqiong Zhang, Meinan Peng, Yue Han, Depei Wu, Aizhen Yang, Yi Wu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-07-01
Schriftenreihe:	Research and Practice in Thrombosis and Haemostasis
Schlagworte:	integrin αIIbβ3 platelet redox thiol isomerase TMX1
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S247503792400219X
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