Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage

Abstract Background Radiation therapy is the standard of care for central nervous system tumours. Despite the success of radiation therapy in reducing tumour mass, irradiation (IR)-induced vasculopathies and neuroinflammation contribute to late-delayed complications, neurodegeneration, and premature...

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Autori principali:	Kshama Gupta, Ralph B. Perkerson, Tammee M. Parsons, Ramacharan Angom, Danilyn Amerna, Jeremy D. Burgess, Yingxue Ren, Pamela J. McLean, Debabrata Mukhopadhyay, Prasanna Vibhute, Zbigniew K. Wszolek, Abba C. Zubair, Alfredo Quiñones-Hinojosa, Takahisa Kanekiyo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2024-07-01
Serie:	Stem Cell Research & Therapy
Soggetti:	iPSC-MSC Radiation therapy Angiogenesis Inflammation Secretome Biotherapeutics
Accesso online:	https://doi.org/10.1186/s13287-024-03847-5
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