TEMPO-derived spin labels linked to the nucleobases adenine and cytosine for probing local structural perturbations in DNA by EPR spectroscopy

Three 2´-deoxynucleosides containing semi-flexible spin labels, namely TA, UA and UC, were prepared and incorporated into deoxyoligonucleotides using the phosphoramidite method. All three nucleosides contain 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) connected to the exocyclic amino group; TA dire...

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Hauptverfasser:	Dnyaneshwar B. Gophane, Snorri Th. Sigurdsson
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Beilstein-Institut 2015-02-01
Schriftenreihe:	Beilstein Journal of Organic Chemistry
Schlagworte:	aminoxyl radical ESR spectroscopy nitroxide nucleic acids site-directed spin labeling (SDSL) spin labels structure-dependent dynamics
Online-Zugang:	https://doi.org/10.3762/bjoc.11.24
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