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Chemoselective N-acylation of indoles using thioesters as acyl source

The selective acylation of indoles often requires sensitive and reactive acyl chloride derivatives. Here, we report a mild, efficient, functional group tolerant, and highly chemoselective N-acylation of indoles using thioesters as a stable acyl source. A series of indoleamides have been obtained wit...

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Principais autores: Tianri Du, Xiangmu Wei, Honghong Xu, Xin Zhang, Ruiru Fang, Zheng Yuan, Zhi Liang, Yahui Li
פורמט: Artigo
שפה:Inglês
יצא לאור: Beilstein-Institut 2022-01-01
סדרה:Beilstein Journal of Organic Chemistry
נושאים:
indole
n-acylation
nucleophilic substitution
thioesters
גישה מקוונת:https://doi.org/10.3762/bjoc.18.9
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