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A synthetic biology approach to probing nucleosome symmetry

The repeating subunit of chromatin, the nucleosome, includes two copies of each of the four core histones, and several recent studies have reported that asymmetrically-modified nucleosomes occur at regulatory elements in vivo. To probe the mechanisms by which histone modifications are read out, we d...

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Principais autores: Yuichi Ichikawa, Caitlin F Connelly, Alon Appleboim, Thomas CR Miller, Hadas Jacobi, Nebiyu A Abshiru, Hsin-Jung Chou, Yuanyuan Chen, Upasna Sharma, Yupeng Zheng, Paul M Thomas, Hsuiyi V Chen, Vineeta Bajaj, Christoph W Müller, Neil L Kelleher, Nir Friedman, Daniel NA Bolon, Oliver J Rando, Paul D Kaufman
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2017-09-01
Colecção:eLife
Assuntos:
chromatin
transcription
synthetic biology
Acesso em linha:https://elifesciences.org/articles/28836
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