Immune Cell-Specific and Isoform-Selective Regulation of CD44 in Pancreatic Ductal Adenocarcinoma Links Lymph Node Variant Loss and Exosomal CD44 to Clinical Outcome in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is characterized by immune cell dysfunction and poor prognosis. CD44, a cell surface glycoprotein with multiple splice variants, has been implicated in tumor progression, but its compartment-specific roles in PDAC remain unclear. CD44 standard and variant isof...

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Bibliografski detalji

Glavni autori:	Alara Karabiber, Yong Zhou, Anke Mittelstädt, Frederik Johannes Hansen, Melanie Litau, Isabelle Kuchenreuther, Johanne Mazurie, Finn Niklas Clausen, Sebastian Klöckner, Franziska Czubayko, Nadine Weisel, Bettina Klösch, Talida Andert-Veres, Stefanie Kröber, Susanne Merkel, Andreas R. R. Weiss, Maximilian Brunner, Christian Krautz, Robert Grützmann, Georg F. Weber, Paul David
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2026-02-01
Serija:	Cells
Teme:	CD44 variants lymph nodes exosomes PDAC immune checkpoints metastasis
Online pristup:	https://www.mdpi.com/2073-4409/15/5/411
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