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JAK inhibitors in systemic juvenile idiopathic arthritis

ObjectiveSystemic juvenile idiopathic arthritis (SJIA) is characterized by excessive and inappropriate production of proinflammatory cytokines. Janus kinase inhibitors (JAKi) can block the downstream pathway of many cytokines. The use of JAKi in SJIA or macrophage activation syndrome (MAS) has only...

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Principais autores: Tingyan He, Yu Xia, Ying Luo, Jun Yang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-04-01
Serier:Frontiers in Pediatrics
Fag:
systemic juvenile idiopathic arthritis
JAK inhibitor
macrophage activation syndrome
tofacitinib
ruxolitinib
Online adgang:https://www.frontiersin.org/articles/10.3389/fped.2023.1134312/full
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