Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons

Pathogenic variants in SPG11 are the most frequent cause of autosomal recessive complicated hereditary spastic paraplegia (HSP). In addition to spastic paraplegia caused by corticospinal degeneration, most patients are significantly affected by progressive weakness and muscle wasting due to alpha mo...

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Autors principals:	Fabian Güner, Tatyana Pozner, Florian Krach, Iryna Prots, Sandra Loskarn, Ursula Schlötzer-Schrehardt, Jürgen Winkler, Beate Winner, Martin Regensburger
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2021-07-01
Col·lecció:	Frontiers in Neuroscience
Matèries:	SPG11 hereditary spastic paraplegia alpha motor neuron induced pluripotent stem cells mitochondria axonal transport
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fnins.2021.680572/full
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