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Overcoming antibody-resistant SARS-CoV-2 variants with bispecific antibodies constructed using non-neutralizing antibodies

Summary: A current challenge is the emergence of SARS-CoV-2 variants, such as BQ.1.1 and XBB.1.5, that can evade immune defenses, thereby limiting antibody drug effectiveness. Emergency-use antibody drugs, including the widely effective bebtelovimab, are losing their benefits. One potential approach...

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Huvudupphov: Tetsuya Inoue, Yuichiro Yamamoto, Kaoru Sato, Yuko Okemoto-Nakamura, Yoshimi Shimizu, Motohiko Ogawa, Taishi Onodera, Yoshimasa Takahashi, Takaji Wakita, Mika K. Kaneko, Masayoshi Fukasawa, Yukinari Kato, Kohji Noguchi
Materialtyp: Artigo
Språk:Inglês
Utgiven: Elsevier 2024-04-01
Serie:iScience
Ämnen:
Natural sciences
Biological sciences
Biochemistry
Immunology
Microbiology
Länkar:http://www.sciencedirect.com/science/article/pii/S2589004224005844
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