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Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA

The spliceosome removes introns from precursor messenger RNAs to produce mature mRNAs. Here the authors report a U6 snRNP crystal structure that provides insight on how the 3′ phosphate of U6 snRNA is recognized by the Lsm2–8 complex and how the U6 snRNP proteins sequester and protect the active sit...

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Detalles Bibliográficos
Principais autores: Eric J. Montemayor, Allison L. Didychuk, Allyson D. Yake, Gurnimrat K. Sidhu, David A. Brow, Samuel E. Butcher
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2018-05-01
Series:Nature Communications
Acceso en liña:https://doi.org/10.1038/s41467-018-04145-4
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