Albumin-Mediated Size Exclusion Chromatography: The Apparent Molecular Weight of PSMA Radioligands as Novel Parameter to Estimate Their Blood Clearance Kinetics

A meticulously adjusted pharmacokinetic profile and especially fine-tuned blood clearance kinetics are key characteristics of therapeutic radiopharmaceuticals. We, therefore, aimed to develop a method that allowed the estimation of blood clearance kinetics in vitro. For this purpose, ¹⁷⁷L...

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Principais autores:	Jan-Philip Kunert, Sebastian Fischer, Alexander Wurzer, Hans-Jürgen Wester
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-09-01
coleção:	Pharmaceuticals
Assuntos:	albumin plasma protein binding blood clearance pharmacokinetics size exclusion chromatography radioligand therapy
Acesso em linha:	https://www.mdpi.com/1424-8247/15/9/1161
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