ACW-02 an Acridine Triazolidine Derivative Presents Antileishmanial Activity Mediated by DNA Interaction and Immunomodulation

The present study proposed the synthesis of a novel acridine derivative not yet described in the literature, chemical characterization by NMR, MS, and IR, followed by investigations of its antileishmanial potential. In vitro assays were performed to assess its antileishmanial activity against <i>L....

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Sonaly Lima Albino, Willian Charles da Silva Moura, Malu Maria Lucas dos Reis, Gleyton Leonel Silva Sousa, Pablo Rayff da Silva, Mayara Gabriele Carvalho de Oliveira, Tatiana Karla dos Santos Borges, Lucas Fraga Friaça Albuquerque, Sinara Mônica Vitalino de Almeida, Maria do Carmo Alves de Lima, Selma Aparecida Souza Kuckelhaus, Igor José dos Santos Nascimento, Francisco Jaime Bezerra Mendonca Junior, Teresinha Gonçalves da Silva, Ricardo Olímpio de Moura
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2023-01-01
Цуврал:	Pharmaceuticals
Нөхцлүүд:	leishmaniasis immunomodulation DNA binding molecular docking molecular dynamics
Онлайн хандалт:	https://www.mdpi.com/1424-8247/16/2/204
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!