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Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

Abstract Background G-protein coupled receptors (GPCRs) are recognized as attractive targets for drug therapy. However, it remains poorly understood how GPCRs, except for a few chemokine receptors, regulate the progression of liver fibrosis. Here, we aimed to reveal the role of GPR65, a proton-sensi...

Ful tanımlama

Kaydedildi:
Asıl Yazarlar: Kun Zhang, Meng-Xia Zhang, Xiao-Xiang Meng, Jing Zhu, Jia-Jun Wang, Yi-Fan He, Ye-Hua Li, Si-Cong Zhao, Zhe-Min Shi, Li-Na Zheng, Tao Han, Wei Hong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: KeAi Communications Co., Ltd. 2023-11-01
Seri Bilgileri:Military Medical Research
Konular:
GPR65
Hepatic fibrosis
Hepatic macrophages
Inflammation
JNK
NF-κB
Online Erişim:https://doi.org/10.1186/s40779-023-00494-4
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