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Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A

Abstract The ever-growing rise of antibiotic resistance among bacterial pathogens is one of the top healthcare threats today. Although combination antibiotic therapies represent a potential approach to more efficiently combat infections caused by susceptible and drug-resistant bacteria, only a few k...

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Principais autores: Chih-Wei Chen, Nadja Leimer, Egor A. Syroegin, Clémence Dunand, Zackery P. Bulman, Kim Lewis, Yury S. Polikanov, Maxim S. Svetlov
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2023-07-01
coleção:Nature Communications
Acesso em linha:https://doi.org/10.1038/s41467-023-39653-5
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