Estradiol treatment induces both shared and unique gene regulation and networks in adipose cell types of gonadectomized obese XX and XY mice

Abstract Background Obesity is driven by the pathological expansion and accumulation of adipose tissue and demonstrates sex differences. Estradiol (E2) is known to influence fat distribution and metabolism. However, a comprehensive understanding of the sex-specific effect of E2 on individual adipose...

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Ngā kaituhi matua:	Yutian Zhao, Ruoshui Liu, Jonathan P. Ng, Sophia Yu, In Sook Ahn, Graciel Diamante, Guanglin Zhang, Ariel Thorson, Kelsey P. Schaefers, John M. Stafford, Xia Yang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	BMC 2026-02-01
Rangatū:	Biology of Sex Differences
Ngā marau:	Estradiol Estrogen therapy Visceral adipose tissue Adipose stem and progenitor cell Macrophage Single-cell RNA sequencing
Urunga tuihono:	https://doi.org/10.1186/s13293-026-00859-z
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!