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NALIRIFOX versus gemcitabine plus nab-paclitaxel in Chinese patients with advanced pancreatic adenocarcinoma: a randomized, open-label phase II trial

Abstract In this phase 2 study (NCT05047991), patients with unresectable metastatic pancreatic adenocarcinoma were randomized to receive NALIRIFOX (liposomal irinotecan, 5-FU, leucovorin, and oxaliplatin) or gemcitabine plus nab-paclitaxel. The primary endpoint was progression free survival (PFS). S...

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Principais autores: Chuntao Gao, Yanqiao Zhang, Xiujuan Qu, Xingyun Chen, Jingdong Zhang, Heshui Wu, Meili Sun, Yong Zha, Junbin Wang, Yusheng Wang, Zhihua Li, Jinghua Gao, Rongbo Lin, Aimin Zang, Huiqing Zhang, Xianglin Yuan, Chengyou Du, Jun Zhao, Yongsheng Yang, Xuetao Shi, Wei Cheng, Bangmao Wang, Shikai Wu, Tiansuo Zhao, Jian Wang, Song Gao, Xiuchao Wang, Weidong Ma, Rui Liu, Yehui Shi, Yanping Liu, Yijiao Xie, Miao Niu, Fuchen Zhao, Jun Yu, Jihui Hao
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-01-01
Serier:Nature Communications
Online adgang:https://doi.org/10.1038/s41467-026-68409-0
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