HSP90AB1‐Mediated Ubiquitin‐Proteasome Degradation of ITGBL1 Promotes Osteosarcoma Progression by Inhibiting Endoplasmic Reticulum Stress‐Induced Autophagy

ABSTRACT Osteosarcoma (OS) is one of the most malignant bone tumors in children and adolescents, but the molecular mechanisms of OS progression remain largely undefined. In this study, we demonstrate that Integrin subunit beta‐like 1 (ITGBL1) is downregulated in OS tissues, and its downregulation co...

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Bibliografische Detailangaben

Hauptverfasser:	Zhen Wang, Zixuan Guo, Chengwei Cao, Ziying Wang, Zifu Huang, Xiujuan Zhang, Yushu Zheng, Diankun She, Hao Zhu, Lingfeng Yu, Xuelin Zhao, Dongquan Xiang, Song Liao, Xin He, Xintong Ji, Chengsheng Wu, Cheng‐Xiong Xu, Meng Xu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2026-04-01
Schriftenreihe:	Advanced Science
Schlagworte:	Autophagy ER stress HSP90AB1 ITGBL1 K63‐linked ubiquitination Osteosarcoma
Online-Zugang:	https://doi.org/10.1002/advs.202515651
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