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Inhibition of PERK Kinase, an Orchestrator of the Unfolded Protein Response (UPR), Significantly Reduces Apoptosis and Inflammation of Lung Epithelial Cells Triggered by SARS-CoV-2 ORF3a Protein

SARS-CoV-2 ORF3a accessory protein was found to be involved in virus release, immunomodulation and exhibited a pro-apoptotic character. In order to unravel a potential ORF3a-induced apoptotic and inflammatory death mechanism, lung epithelial cells (A549) were transfected with in vitro synthesized <i...

Täydet tiedot

Tallennettuna:
Päätekijät: Panagiotis Keramidas, Eleni Papachristou, Rigini M. Papi, Aglaia Mantsou, Theodora Choli-Papadopoulou
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI AG 2023-05-01
Sarja:Biomedicines
Aiheet:
SARS-CoV-2
ORF3a
apoptosis
ER stress
pyroptosis
cytokine storm
Linkit:https://www.mdpi.com/2227-9059/11/6/1585
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