Spatial transcriptomics reveals the molecular signatures of prodromal and advanced α-synucleinopathy

Summary: A pathological role of α-synuclein (aSyn) aggregation in the etiology of Parkinson disease (PD) is well established. Here, we applied spatial transcriptomics (ST) on brain sections derived from a rodent mouse model of α-synucleinopathy (transgenic M83+/+ line). Our ST data revealed that ind...

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Bibliografiske detaljer

Principais autores:	Lin Lin, Nanna M. Jensen, Alberto Delaidelli, Sara A. Ferreira, Fatemeh Yarmahmoudi, Poul H. Sorensen, Marina Romero-Ramos, Poul H. Jensen, Ian R. Mackenzie, Jens R. Nyengaard, Asad Jan
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2026-03-01
Serier:	iScience
Fag:	Model organism Molecular neuroscience Protein structure aspects Transcriptomics
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2589004226002208
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