HMGB1 impairs nasal mucosa epithelial barrier function in allergic rhinitis by promoting BECN1-mediating autophagy

As a potent proinflammatory cytokine, high mobility group box 1 (HMGB1) exacerbates nasal mucosal epithelial barrier dysfunction. This study elucidates the mechanistic role of HMGB1 in driving epithelial barrier impairment in allergic rhinitis (AR). HMGB1 knockdown in human nasal epithelial cells (h...

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Bibliografische Detailangaben

Hauptverfasser:	Zhaoen Ma, Langrui Tu, Xiaobin Yang, Min Mao, Guangui Chen, Fenghong Chen, Libing Liao, Yali Xu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2025-12-01
Schriftenreihe:	Biochemistry and Biophysics Reports
Schlagworte:	High mobility group box 1 Nasal mucosal epithelial barrier dysfunction Autophagy BECN1
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2405580825004388
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